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New approaches for the prevention of rejection and graft-vs.-host disease in clinical bone marrow transplantation.

Abstract:

The two major barriers to successful allogeneic bone marrow transplantation (BMT) in animals and man are graft-vs.-host disease (GVHD) and the risk of graft rejection. GVHD is the result of alloreactivity of mature donor T-lymphocytes present in the graft-vs.-host tissues and can be completely prevented by pregraft depletion of T-lymphocytes. Graft rejection results from residual host immunocompetent lymphocytes that survive heavy chemoradiotherapy prior to allogeneic BMT. Host resistance to ...

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Publication status:
Published

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Journal:
Israel journal of medical sciences More from this journal
Volume:
22
Issue:
3-4
Pages:
264-267
Publication date:
1986-01-01
ISSN:
0021-2180
Language:
English
Keywords:
Pubs id:
pubs:17045
UUID:
uuid:b84e5d6b-1549-4d6c-9748-9ee07667c392
Local pid:
pubs:17045
Source identifiers:
17045
Deposit date:
2012-12-19

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