New approaches for the prevention of rejection and graft-vs.-host disease in clinical bone marrow transplantation.

Journal article

The two major barriers to successful allogeneic bone marrow transplantation (BMT) in animals and man are graft-vs.-host disease (GVHD) and the risk of graft rejection. GVHD is the result of alloreactivity of mature donor T-lymphocytes present in the graft-vs.-host tissues and can be completely prevented by pregraft depletion of T-lymphocytes. Graft rejection results from residual host immunocompetent lymphocytes that survive heavy chemoradiotherapy prior to allogeneic BMT. Host resistance to ...

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Authors: Slavin, S; Or, R; Naparstek, E; Cividalli, G; Weshler, Z

• Publication status: Published
• Journal: Israel journal of medical sciences
• Volume: 22
• Issue: 3-4
• Pages: 264-267
• Publication date: 1986-01-01
• ISSN: 0021-2180
• Language: English
• Keywords: Humans; Graft Enhancement, Immunologic; Graft vs Host Disease; Hematologic Diseases; Leukocyte Count; Bone Marrow Cells; Bone Marrow Transplantation; T-Lymphocytes; Lymphatic System; Antilymphocyte Serum