Journal article
Tumor-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice
- Abstract:
-
CD4(+) Foxp3(+) regulatory T cells (Treg) include differentiated populations of effector Treg characterized by the expression of specific transcription factors. Tumors, including intestinal malignancies, often present with local accumulation of Treg that can prevent tumor clearance, but how tumor progression leads to Treg accumulation is incompletely understood. Here using genetically modified mouse models we show that ablation of E-cadherin, a process associated with epithelial to mesenchyma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Max Planck Society
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Bibliographic Details
- Publisher:
- John Wiley & Sons Ltd Publisher's website
- Journal:
- Immunology Journal website
- Volume:
- 152
- Issue:
- 1
- Pages:
- 74-88
- Publication date:
- 2017-04-24
- Acceptance date:
- 2017-04-19
- DOI:
- EISSN:
-
1365-2567
- ISSN:
-
0019-2805
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:692380
- UUID:
-
uuid:b84d6cd6-22c5-40b3-8852-53c51a4bcd7f
- Local pid:
- pubs:692380
- Source identifiers:
-
692380
- Deposit date:
- 2017-06-15
Terms of use
- Copyright holder:
- John Wiley & Sons Ltd
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 John Wiley & Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/imm.12750
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