Increased IgA rheumatoid factor and V(H)1 associated cross reactive idiotype expression in patients with Lyme arthritis and neuroborreliosis.

Journal article

OBJECTIVE: To investigate whether autoreactive mechanisms occur in Lyme disease (LD) by determining IgA, IgG and IgM rheumatoid factor (RF) concentrations and RF associated cross reactive idiotype (CRI) expression in the serum of LD patients, with comparison to patients with rheumatoid arthritis (RA). METHODS: The RF isotype profiles were determined in 59 patients with LD; erythema migrans (EM) (n=19), neuroborreliosis (NB) (n=20) and Lyme arthritis (LA) (n=20). Mouse monoclonal antibodies (m...

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Authors: Axford, J; Rees, D; Mageed, R; Wordsworth, P; Alavi, A

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 58
• Issue: 12
• Pages: 757-761
• Publication date: 1999-12-01
• DOI: 10.1136/ard.58.12.757
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Cross Reactions; Humans; Middle Aged; Female; Immunoglobulin Heavy Chains; Arthritis, Rheumatoid; Arthritis, Infectious; Male; Erythema Chronicum Migrans; Adolescent; Rheumatoid Factor; Lyme Neuroborreliosis; Lyme Disease; Immunoglobulin M; Immunoglobulin Idiotypes; Immunoglobulin A; Adult; Child