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Journal article

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes Ca(2+) in many cells and species. Unlike other Ca(2+)-mobilizing messengers, NAADP mobilizes Ca(2+) from an unknown store that is not the endoplasmic reticulum, the store traditionally associated with messenger-mediated Ca(2+) signaling. Here, we demonstrate the presence of a Ca(2+) store in sea urchin eggs mobilized by NAADP that is dependent on a proton gradient maintained by an ATP-dependent vacuolar-type proton pump. Moreover...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Cell
Volume:
111
Issue:
5
Pages:
703-708
Publication date:
2002-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:b84a22a0-302e-45ed-b39a-706981b2d3a1
Source identifiers:
106523
Local pid:
pubs:106523

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