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Journal article

Bifunctional crosslinking ligands for transthyretin.

Abstract:

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precursor proteins arrests amyloid deposition and halts disease progression in all forms of amyloidosis including TTR type. Our previous demonstration that circulating serum amyloid P component (SAP) is...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsob.150105

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Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
5
Issue:
9
Pages:
150105
Publication date:
2015-09-01
DOI:
EISSN:
2046-2441
ISSN:
2046-2441
Source identifiers:
569853
Language:
English
Keywords:
Pubs id:
pubs:569853
UUID:
uuid:b842d588-349f-4dc0-a413-be459cd248c1
Local pid:
pubs:569853
Deposit date:
2016-02-03

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