Bifunctional crosslinking ligands for transthyretin.
Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precursor proteins arrests amyloid deposition and halts disease progression in all forms of amyloidosis including TTR type. Our previous demonstration that circulating serum amyloid P component (SAP) is...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 797.4KB)
- Publisher copy:
- Copyright holder:
- Mangione et al
- Copyright date:
- © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
If you are the owner of this record, you can report an update to it here: Report update to this record