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Journal article

Bifunctional crosslinking ligands for transthyretin.

Abstract:

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precursor proteins arrests amyloid deposition and halts disease progression in all forms of amyloidosis including TTR type. Our previous demonstration that circulating serum amyloid P component (SAP) is...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rsob.150105

Authors


Mangione, PP More by this author
Ellmerich, S More by this author
Bellotti, V More by this author
Kolstoe, S More by this author
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Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
5
Issue:
9
Pages:
150105
Publication date:
2015-09-05
DOI:
EISSN:
2046-2441
ISSN:
2046-2441
URN:
uuid:b842d588-349f-4dc0-a413-be459cd248c1
Source identifiers:
569853
Local pid:
pubs:569853

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