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Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia.

Abstract:

Acclimatization to altitude involves an increase in the acute hypoxic ventilatory response (AHVR). Because low-dose dopamine decreases AHVR and domperidone increases AHVR, the increase in AHVR at altitude may be generated by a decrease in peripheral dopaminergic activity. The AHVR of nine subjects was determined with and without a prior period of 8 h of isocapnic hypoxia under each of three pharmacological conditions: 1) control, with no drug administered; 2) dopamine (3 microg. min-1. kg-1);...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of applied physiology (Bethesda, Md. : 1985) More from this journal
Volume:
86
Issue:
1
Pages:
222-229
Publication date:
1999-01-01
EISSN:
1522-1601
ISSN:
8750-7587
Language:
English
Keywords:
Pubs id:
pubs:113726
UUID:
uuid:b83fed25-9769-4c4f-9d41-ae2cbd42b5a9
Local pid:
pubs:113726
Source identifiers:
113726
Deposit date:
2013-11-17

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