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Journal article

Imperfect vaccines and the evolution of pathogen virulence.

Abstract:

Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the consequences for public health. Here we show that vaccines designed to reduce pathogen growth rate and/or toxicity diminish selection against virulent pathogens. The subsequent evo...

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Publication status:
Published

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Publisher copy:
10.1038/414751a

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Journal:
Nature
Volume:
414
Issue:
6865
Pages:
751-756
Publication date:
2001-12-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:b83e7341-8b5c-4b44-bd89-90445e3841fb
Source identifiers:
90466
Local pid:
pubs:90466

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