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Journal article

Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis.

Abstract:

Interferon-β (IFN-β) drugs are considered to derive their beneficial effects on multiple sclerosis (MS) progression via their antiinflammatory properties, but the precise mechanism of action remains unclear. Here, we sought to discover how IFN-β impacts on inflammation-associated aggravation of MS-like lesions in rat. Animals with dormant focal experimental allergic encephalomyelitis (EAE) lesions were challenged intravenously with a replication-deficient adenovirus vector carrying interleuki...

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Publication status:
Published

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Publisher copy:
10.1038/jcbfm.2013.12

Authors


Bristow, C More by this author
de Pablos, RM More by this author
Merkler, D More by this author
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Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
33
Issue:
5
Pages:
744-753
Publication date:
2013-05-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:b83b5c9d-572c-4cb9-ad8c-9bd4cbb3c4cb
Source identifiers:
387163
Local pid:
pubs:387163

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