- Abstract:
-
Articular chondrocytes experience low oxygen (O(2)) levels compared with many other tissues, and values fall further in disease states. Chondrocyte intracellular pH (pH(i)) is a powerful modulator of matrix synthesis and is principally regulated by Na(+)-H(+) exchange (NHE). In equine chondrocytes, NHE is inhibited when cells are incubated for 3 h at low O(2), leading to intracellular acidosis. O(2)-dependent changes in reactive oxygen species (ROS) levels appear to underlie this effect. The ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00424-009-0695-6
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- Journal:
- Pflugers Archiv : European journal of physiology
- Volume:
- 458
- Issue:
- 6
- Pages:
- 1085-1092
- Publication date:
- 2009-10-05
- DOI:
- EISSN:
-
1432-2013
- ISSN:
-
0031-6768
- URN:
-
uuid:b8332e0f-be21-455a-b8f8-63c8f90e1565
- Source identifiers:
-
114796
- Local pid:
- pubs:114796
- Copyright date:
- 2009
Journal article
Rapid effects of hypoxia on H+ homeostasis in articular chondrocytes.
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