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Rapid effects of hypoxia on H+ homeostasis in articular chondrocytes.

Abstract:

Articular chondrocytes experience low oxygen (O(2)) levels compared with many other tissues, and values fall further in disease states. Chondrocyte intracellular pH (pH(i)) is a powerful modulator of matrix synthesis and is principally regulated by Na(+)-H(+) exchange (NHE). In equine chondrocytes, NHE is inhibited when cells are incubated for 3 h at low O(2), leading to intracellular acidosis. O(2)-dependent changes in reactive oxygen species (ROS) levels appear to underlie this effect. The ...

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Publication status:
Published

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Publisher copy:
10.1007/s00424-009-0695-6

Authors


Gibson, JS More by this author
McCartney, D More by this author
Sumpter, J More by this author
Fairfax, TP More by this author
Milner, PI More by this author
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Journal:
Pflugers Archiv : European journal of physiology
Volume:
458
Issue:
6
Pages:
1085-1092
Publication date:
2009-10-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:b8332e0f-be21-455a-b8f8-63c8f90e1565
Source identifiers:
114796
Local pid:
pubs:114796

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