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Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

Abstract:

Plasmodium falciparum PfRH5 protein binds Ripr, CyRPA and Pf113 to form a complex that is essential for merozoite invasion of erythrocytes. The inter-genomic conservation of the PfRH5 complex proteins makes them attractive blood stage vaccine candidates. However, little is known about how antibodies to PfRH5, CyRPA and Pf113 are acquired and maintained in naturally exposed populations, and the role of PfRH5 complex proteins in naturally acquired immunity. To provide such data, we studied 206 ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0198371

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Role:
Author
ORCID:
0000-0002-1140-5527
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
6
Pages:
Article: e0198371
Publication date:
2018-06-08
Acceptance date:
2018-05-17
DOI:
EISSN:
1932-6203
Pubs id:
pubs:857297
URN:
uri:b82eebc8-a508-4ba2-a63c-ebeb4df3213f
UUID:
uuid:b82eebc8-a508-4ba2-a63c-ebeb4df3213f
Local pid:
pubs:857297
Language:
English

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