- Abstract:
-
Plasmodium falciparum PfRH5 protein binds Ripr, CyRPA and Pf113 to form a complex that is essential for merozoite invasion of erythrocytes. The inter-genomic conservation of the PfRH5 complex proteins makes them attractive blood stage vaccine candidates. However, little is known about how antibodies to PfRH5, CyRPA and Pf113 are acquired and maintained in naturally exposed populations, and the role of PfRH5 complex proteins in naturally acquired immunity. To provide such data, we studied 206 ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.9MB)
-
(pdf, 275.7KB)
-
- Publisher copy:
- 10.1371/journal.pone.0198371
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 13
- Issue:
- 6
- Pages:
- Article: e0198371
- Publication date:
- 2018-06-08
- Acceptance date:
- 2018-05-17
- DOI:
- EISSN:
-
1932-6203
- Pubs id:
-
pubs:857297
- URN:
-
uri:b82eebc8-a508-4ba2-a63c-ebeb4df3213f
- UUID:
-
uuid:b82eebc8-a508-4ba2-a63c-ebeb4df3213f
- Local pid:
- pubs:857297
- Language:
- English
- Copyright holder:
- Partey et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Partey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Note: an erratum exists for this article, originally published and available at: https://doi.org/10.1371/journal.pone.0204452
Journal article
Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
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