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Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Abstract:

Many epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition between stem cells protects against the acquisition of deleterious mutations. Here we use a Porcupine inhibitor to reduce Wnt secretion at a dose where intestinal homoeostasis is maintained despite a reduction of Lgr5+ stem cells. Functionally, there is a marked acceleration in monoclonal conversion, so that crypts become rapidly derived ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-03426-2

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More from this funder
Grant:
C596/A17196 and grant to OS A12481
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Grant:
CANCER-RECURRENCE 648804 (to J.v.R.)
Doctor Josef Steiner Foundation More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
Article: 1132
Publication date:
2018-03-19
Acceptance date:
2018-02-13
DOI:
ISSN:
2041-1723
Pubs id:
pubs:833167
URN:
uri:b82d9829-54f0-437a-a61a-eb3de9387ef8
UUID:
uuid:b82d9829-54f0-437a-a61a-eb3de9387ef8
Local pid:
pubs:833167
Language:
English

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