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Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Abstract:

Many epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition between stem cells protects against the acquisition of deleterious mutations. Here we use a Porcupine inhibitor to reduce Wnt secretion at a dose where intestinal homoeostasis is maintained despite a reduction of Lgr5+ stem cells. Functionally, there is a marked acceleration in monoclonal conversion, so that crypts become rapidly derived ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Cancer Research UK
Grant:
granttoOSA12481
C596/A17196
More from this funder
Name:
Wellcome Trust
Grant:
RG73636
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Name:
Netherlands Organisation for Scientific Research
Grant:
CancerGenomics.nl
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Name:
European Research Council
Grant:
642866 (to J.v.R
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Name:
Doctor Josef Steiner Foundation
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
9
Issue:
1
Article number:
1132
Publication date:
2018-03-19
Acceptance date:
2018-02-13
DOI:
ISSN:
2041-1723
Pmid:
29556067
Language:
English
Pubs id:
pubs:833167
UUID:
uuid:b82d9829-54f0-437a-a61a-eb3de9387ef8
Local pid:
pubs:833167
Source identifiers:
833167
Deposit date:
2018-05-16

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