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Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil.

Abstract:

Although the intratumoral expression levels of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are known to affect the antitumor activity of 5-fluorouracil (5-FU), the importance of orotate phosphoribosyltransferase (OPRT) has remained unclear. This study investigated the relationship between intratumoral OPRT expression and the antitumor activity of 5-FU using human NCI60 cell lines with similar levels of TS and DPD messenger RNAs, as well as 31 tumor xenografts. The OPRT...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbrc.2007.08.164

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Journal:
Biochemical and biophysical research communications More from this journal
Volume:
363
Issue:
1
Pages:
216-222
Publication date:
2007-11-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Language:
English
Keywords:
Pubs id:
pubs:226985
UUID:
uuid:b82667e3-e48f-48d5-8f6f-a3bb4a35480f
Local pid:
pubs:226985
Source identifiers:
226985
Deposit date:
2012-12-19

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