Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil.

Journal article

Although the intratumoral expression levels of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are known to affect the antitumor activity of 5-fluorouracil (5-FU), the importance of orotate phosphoribosyltransferase (OPRT) has remained unclear. This study investigated the relationship between intratumoral OPRT expression and the antitumor activity of 5-FU using human NCI60 cell lines with similar levels of TS and DPD messenger RNAs, as well as 31 tumor xenografts. The OPRT...

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Authors: Sakamoto, E; Nagase, H; Kobunai, T; Oie, S; Oka, T

• Publication status: Published
• Journal: Biochemical and biophysical research communications
• Volume: 363
• Issue: 1
• Pages: 216-222
• Publication date: 2007-11-01
• DOI: 10.1016/j.bbrc.2007.08.164
• EISSN: 1090-2104
• ISSN: 0006-291X
• Language: English
• Keywords: Humans; Cell Survival; Antineoplastic Agents; Fluorouracil; Neoplasm Proteins; Gene Expression Regulation, Neoplastic; Tumor Markers, Biological; Gene Expression Regulation, Enzymologic; Orotate Phosphoribosyltransferase; Neoplasms; Cell Line, Tumor