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Journal article

Swelling of the intervertebral disc in vitro.

Abstract:
Slices of the intervertebral disc swell rapidly in aqueous solutions. Following swelling, a large proportion of the proteoglycans leach out. These changes can introduce artifacts into in vitro experimental work. Swelling results from the large Gibbs-Donnan osmotic pressure of the proteoglycans which the collagen network of the disc is unable to oppose alone. Swelling can be prevented by applying pressure to disc slices either mechanically or with iso-osmotic solutions.

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Publisher copy:
10.3109/03008208109160234

Authors


Maroudas, A More by this author
Publisher:
Informa Healthcare
Journal:
Connective tissue research
Volume:
9
Issue:
1
Pages:
1-10
Publication date:
1981
DOI:
EISSN:
1607-8438
ISSN:
0300-8207
URN:
uuid:b8244229-7302-4bfa-9577-615eb1ad3501
Source identifiers:
433395
Local pid:
pubs:433395

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