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Journal article

Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy.

Abstract:

UNLABELLED: The efficacy of specifically targeted anti-viral therapy for hepatitis C virus (HCV) (STAT-C), including HCV protease and polymerase inhibitors, is limited by the presence of drug-specific viral resistance mutations within the targeted proteins. Genetic diversity within these viral proteins also evolves under selective pressures provided by host human leukocyte antigen (HLA)-restricted immune responses, which may therefore influence STAT-C treatment response. Here, the prevalence ...

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Publication status:
Published

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Publisher copy:
10.1002/hep.22773

Authors


Gaudieri, S More by this author
Pfafferott, K More by this author
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Journal:
Hepatology (Baltimore, Md.)
Volume:
49
Issue:
4
Pages:
1069-1082
Publication date:
2009-04-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:b8209429-3891-483f-a79f-2bd8be43fd21
Source identifiers:
27286
Local pid:
pubs:27286

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