Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

Journal article

Inflammatory and innate immune signaling in response to recognition of pathogens is essential for immunity and host survival. However, deregulation may lead to detrimental pathologies including immunodeficiency, inflammatory diseases, and cancer. Inhibitor of apoptosis (IAP) proteins have emerged as important regulators of innate immune signaling downstream of pattern recognition receptors (PRRs) such as Toll-like receptor 4 (TLR4), the nucleotide-binding oligomerization domain 1 (NOD1) and N...

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Authors: Damgaard, R; Gyrd-Hansen, M

• Journal: Discovery medicine
• Volume: 11
• Issue: 58
• Pages: 221-231
• Publication date: 2011-03-01
• EISSN: 1944-7930
• ISSN: 1539-6509
• Language: English
• Keywords: Signal Transduction; Immunity, Innate; Inflammation; NF-kappa B; Humans; Animals; Inhibitor of Apoptosis Proteins; Nod2 Signaling Adaptor Protein; Toll-Like Receptor 4