Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice.

Journal article

Thalamo-cortical networks generate specific patterns of oscillations during distinct vigilance states and epilepsy, well characterized by electroencephalography (EEG). Oscillations depend on recurrent synaptic loops, which are controlled by GABAergic transmission. In particular, GABA A receptors containing the alpha3 subunit are expressed predominantly in cortical layer VI and thalamic reticular nucleus (nRT) and regulate the activity and firing pattern of neurons in relay nuclei. Therefore, ...

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Authors: Winsky-Sommerer, R; Knapman, A; Fedele, D; Schofield, C; Vyazovskiy, V

• Journal: Neuroscience
• Volume: 154
• Issue: 2
• Pages: 595-605
• Publication date: 2008-06-01
• DOI: 10.1016/j.neuroscience.2008.03.081
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Arousal; Phenotype; Electroencephalography; Thalamus; Receptors, GABA-A; Mice, Inbred C57BL; Sleep; Kainic Acid; Mice; Patch-Clamp Techniques; Electrodes, Implanted; Data Interpretation, Statistical; Excitatory Amino Acid Antagonists; Electrophysiology; Animals; Carrier Proteins; Mice, Knockout; Homeostasis; Motor Activity; Epilepsy; Fluorescent Antibody Technique; Membrane Proteins; Sleep Stages