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An in silico model of cytotoxic T-lymphocyte activation in the lymph node following short peptide vaccination

Abstract:

Tumour immunotherapy is dependent upon activation and expansion of tumour targetting immune cells, known as Cytotoxic T-Lymphocytes (CTLs). Cancer vaccines developed in the past have had limited success and the mechanisms resulting in failure are not well characterised. To elucidate these mechanisms, we developed a human parameterised, in silico, agent based model of vaccination-driven CTL activation within a clinical short-peptide vaccination context. The simulations predict a sharp tran...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1098/rsif.2018.0041

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
Brasenose College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
Clarendon Fund More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Journal of the Royal Society Interface Journal website
Volume:
15
Issue:
140
Pages:
Article: 20180041
Publication date:
2018-03-14
Acceptance date:
2018-02-16
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Pubs id:
pubs:831339
URN:
uri:b80bb612-dfee-4ebe-ab44-8d3112f4ea1c
UUID:
uuid:b80bb612-dfee-4ebe-ab44-8d3112f4ea1c
Local pid:
pubs:831339
Paper number:
140

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