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Pre-clinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria.

Abstract:

The aim of this study was to identify candidate antivenoms with specific activity against the venom of the saw-scaled or carpet viper (Echis ocellatus) in northern Nigeria, where bites by this species cause great morbidity and mortality but where effective antivenoms have become scarce and unaffordable. Selected antivenoms were destined to be compared by randomised controlled clinical trials (RCTs). Standard pre-clinical neutralisation assays were carried out in rodents. We included two licen...

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Publication status:
Published

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Journal:
Toxicon : official journal of the International Society on Toxinology
Volume:
55
Issue:
4
Pages:
719-723
Publication date:
2010-04-05
DOI:
EISSN:
1879-3150
ISSN:
0041-0101
URN:
uuid:b809dd7f-95aa-4e9c-8a0e-a398e62a5888
Source identifiers:
61062
Local pid:
pubs:61062

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