Journal article
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex
- Abstract:
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Background A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). Methods We investigated mutations in 92 genes implicated in resistance to 21 anti-tuberculosis drugs using the genomes of 405 phylogenetically diverse MTBC strains. The role of phylogenetically informative mut...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, 2.8MB)
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- Publisher copy:
- 10.1186/s13073-020-00726-5
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Authors
Bibliographic Details
- Publisher:
- BMC Publisher's website
- Journal:
- Genome Medicine Journal website
- Volume:
- 12
- Issue:
- 1
- Article number:
- 27
- Publication date:
- 2020-03-06
- Acceptance date:
- 2020-02-25
- DOI:
- EISSN:
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1756-994X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1091926
- Local pid:
- pubs:1091926
- Deposit date:
- 2020-03-09
Terms of use
- Copyright holder:
- Merker et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s). 2020 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Licence:
- CC Attribution (CC BY)
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