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Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

Abstract:

Background A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). Methods We investigated mutations in 92 genes implicated in resistance to 21 anti-tuberculosis drugs using the genomes of 405 phylogenetically diverse MTBC strains. The role of phylogenetically informative mut...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13073-020-00726-5

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Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0003-0912-4483
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Publisher:
BMC Publisher's website
Journal:
Genome Medicine Journal website
Volume:
12
Issue:
1
Article number:
27
Publication date:
2020-03-06
Acceptance date:
2020-02-25
DOI:
EISSN:
1756-994X
Language:
English
Keywords:
Pubs id:
1091926
Local pid:
pubs:1091926
Deposit date:
2020-03-09

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