The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.

Journal article

On the western border of Thailand, Plasmodium falciparum has become resistant to almost all antimalarial agents. The molecular basis of resistance in these parasite populations has not been well characterized. This study assessed genetic polymorphisms in the pfmdr1 gene in 54 parasites collected from the western border of Thailand to determine the relationship of pfmdr1 copy number and codon mutations with parasite sensitivities to mefloquine, chloroquine, halofantrine, quinine, and artesunat...

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Authors: Price, R; Cassar, C; Brockman, A; Duraisingh, M; van Vugt, M

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 43
• Issue: 12
• Pages: 2943-2949
• Publication date: 1999-12-01
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Humans; Gene Dosage; Alleles; Mefloquine; Malaria, Falciparum; Plasmodium falciparum; Antigens, Protozoan; Phenotype; Genetic Markers; Reverse Transcriptase Polymerase Chain Reaction; Thailand; Animals; DNA, Protozoan; Drug Resistance, Multiple; Codon; ATP-Binding Cassette Transporters; Antimalarials; Polymorphism, Genetic; Protozoan Proteins