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Journal article

Aversive learning and appetitive motivation toggle feed-forward inhibition in the Drosophila mushroom body

Abstract:

In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-γ1pedc>α/β. However, MVP2 neuron output is only essential for expression of short-term aversive memory. Stimulating MV...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
Bettencourt-Schueller Foundation
Funding agency for:
Waddell, S
More from this funder
Name:
Oxford Martin School
Funding agency for:
Waddell, S
More from this funder
Name:
Gatsby Charitable Foundation
Funding agency for:
Waddell, S
More from this funder
Name:
Wellcome Trust Senior Research Fellowship
Funding agency for:
Waddell, S
More from this funder
Name:
University College War Memorial Studentship
Funding agency for:
Barnstedt, O
Publisher:
Cell Press
Journal:
Neuron More from this journal
Volume:
90
Issue:
5
Pages:
1086-1099
Publication date:
2016-05-19
Acceptance date:
2016-04-19
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Language:
English
Pubs id:
pubs:623860
UUID:
uuid:b80188c1-7a9e-4438-bb21-51b3131e9e31
Local pid:
pubs:623860
Source identifiers:
623860
Deposit date:
2016-06-21

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