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Journal article

Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation.

Abstract:

BACKGROUND: Platelet-activating factor is a mediator of lung injury during cardiac operation. Platelet-activating factor antagonists reduce lung injury in animal models of cardiopulmonary bypass but there is no confirmatory evidence in clinical practice. METHODS: The effect of a low or high dose of a platelet-activating factor antagonist (Lexipafant) was assessed in a single center, double-blind, placebo-controlled, parallel group study. One hundred fifty patients undergoing coronary artery b...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Annals of thoracic surgery More from this journal
Volume:
71
Issue:
1
Pages:
238-242
Publication date:
2001-01-01
DOI:
EISSN:
1552-6259
ISSN:
0003-4975
Language:
English
Keywords:
Pubs id:
pubs:141164
UUID:
uuid:b7fd82f1-2c9c-44f6-a63b-0e094f8ef5f2
Local pid:
pubs:141164
Source identifiers:
141164
Deposit date:
2012-12-19

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