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Quantitation of X-Y homologous genes in patients with schizophrenia by multiplex polymerase chain reaction.

Abstract:

OBJECTIVES: The genetic basis of schizophrenia is obscure. In an XX male patient with schizophrenia we previously showed that one X;Y translocation breakpoint was in pseudoautosomal region 1 (PAR1) with the effect that the proximal segment of PAR1 from the PAR1 boundary to acetylserotonin N-methyl transferase (ASMT) distally was triplicated in this patient. This study determined whether dosage imbalances of X-Y homologous regions in general are associated with schizophrenia. METHODS: A multi...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Psychiatric genetics
Volume:
13
Issue:
2
Pages:
115-119
Publication date:
2003-06-01
DOI:
EISSN:
1473-5873
ISSN:
0955-8829
Source identifiers:
32373

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