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Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.

Abstract:

Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to Mycobacterium marinum can result from either inadequate or excessive acute inflammation. Modulation of the leukotriene A(4) hydrolase (LTA4H) locus, which controls the balance of pro- and anti-inflammatory eicosanoids, reveals two distinct molecular routes to mycobacterial susceptibility converging on dysregulated T...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2011.12.023

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Journal:
Cell More from this journal
Volume:
148
Issue:
3
Pages:
434-446
Publication date:
2012-02-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674

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