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Journal article

Modeling cardiac ischemia.

Abstract:

Myocardial ischemia is one of the main causes of sudden cardiac death, with 80% of victims suffering from coronary heart disease. In acute myocardial ischemia, the obstruction of coronary flow leads to the interruption of oxygen flow, glucose, and washout in the affected tissue. Cellular metabolism is impaired and severe electrophysiological changes in ionic currents and concentrations ensue, which favor the development of lethal cardiac arrhythmias such as ventricular fibrillation. Due to th...

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Publication status:
Published

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Publisher copy:
10.1196/annals.1380.029

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Annals of the New York Academy of Sciences More from this journal
Volume:
1080
Issue:
1
Pages:
395-414
Publication date:
2006-10-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
Language:
English
Keywords:
Pubs id:
pubs:237172
UUID:
uuid:b7ee5430-da15-43b4-89a2-115d9523201f
Local pid:
pubs:237172
Source identifiers:
237172
Deposit date:
2013-11-16

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