Journal article
Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.
- Abstract:
-
Epstein-Barr virus-induced gene-3 (EBI-3) associates with p28 to form interleukin-27 (IL-27) or with IL-12p35 to form IL-35. Both IL-27 and IL-35 have immunosuppressive functions and especially IL-35 has been implicated in the suppressive function of regulatory T cells (Treg). To address the role of EBI-3 in immune regulation, delayed-type hypersensitivity (DTH) responses were examined in EBI-3-deficient (EBI-3(-/-)) mice. EBI-3(-/-) mice developed deteriorated DTH responses as shown by the e...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.imlet.2010.01.001
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Authors
Bibliographic Details
- Journal:
- Immunology letters
- Volume:
- 128
- Issue:
- 2
- Pages:
- 108-115
- Publication date:
- 2010-02-05
- DOI:
- EISSN:
-
1879-0542
- ISSN:
-
0165-2478
- URN:
-
uuid:b7e688c1-f437-4c48-b719-383076f9ac70
- Source identifiers:
-
51991
- Local pid:
- pubs:51991
Item Description
Terms of use
- Copyright date:
- 2010
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