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Journal article

Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.

Abstract:

Epstein-Barr virus-induced gene-3 (EBI-3) associates with p28 to form interleukin-27 (IL-27) or with IL-12p35 to form IL-35. Both IL-27 and IL-35 have immunosuppressive functions and especially IL-35 has been implicated in the suppressive function of regulatory T cells (Treg). To address the role of EBI-3 in immune regulation, delayed-type hypersensitivity (DTH) responses were examined in EBI-3-deficient (EBI-3(-/-)) mice. EBI-3(-/-) mice developed deteriorated DTH responses as shown by the e...

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Publication status:
Published

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Publisher copy:
10.1016/j.imlet.2010.01.001

Authors


Miyazaki, Y More by this author
Yamazaki, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Immunology letters
Volume:
128
Issue:
2
Pages:
108-115
Publication date:
2010-02-05
DOI:
EISSN:
1879-0542
ISSN:
0165-2478
URN:
uuid:b7e688c1-f437-4c48-b719-383076f9ac70
Source identifiers:
51991
Local pid:
pubs:51991

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