Lung cancers detected by screening with spiral computed tomography have a malignant phenotype when analyzed by cDNA microarray

Journal article

Purpose: Spiral computed tomography (CT) can detect lung cancer at an early stage, but the malignant potential is unknown. The question is, as follows: do these small lesions have the same lethal potential as do symptomatic tumors? Experimental Design: We used a cDNA microarray platform and compared the gene expression profile of spiral CT-detected lung carcinomas with a matched case-control population of patients presenting with symptomatic lung cancer. Results: CT-detected and symptomatic t...

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Authors: Bianchi, F; Hu, J; Pelosi, G; Cirincione, R; Ferguson, M

• Journal: Clinical Cancer Research
• Volume: 10
• Issue: 18 I
• Pages: 6023-6028
• Publication date: 2004-09-15
• DOI: 10.1158/1078-0432.CCR-04-0619
• EISSN: 1557-3265
• ISSN: 1078-0432
• Language: English