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Journal article

Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts.

Abstract:

Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mouse and rat to human) and throughout the different regions of the small and large intestines. In this article, we construct a partial differential equation model of a single colonic crypt that describes the spatial distribution of Wnt pathway pr...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2010.05.016

Authors


Murray, PJ More by this author
Mirams, GR More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
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Journal:
Biophysical journal
Volume:
99
Issue:
3
Pages:
716-725
Publication date:
2010-08-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:b7dc1da5-b560-442f-ba20-f2470564633c
Source identifiers:
67590
Local pid:
pubs:67590

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