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Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

Abstract:

Clinically effective antidepressants are thought to exert their therapeutic effects by facilitating central monoamine neurotransmission. However, recent data showing that neurokinin-1 receptor (NK1R) antagonists have antidepressant properties in both animal and clinical studies raise the possibility that classical antidepressants may also influence NK1R expression in the brain. To test this hypothesis, rats were treated with desipramine, paroxetine, venlafaxine, tranylcypromine or vehicle for...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuropharmacology
Volume:
46
Issue:
8
Pages:
1177-1183
Publication date:
2004-06-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:b7d6eb74-79bd-484d-b764-c3729558af8a
Source identifiers:
139419
Local pid:
pubs:139419

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