Journal article
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
- Abstract:
-
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between rupture...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Contributors
+ HUNT All-In Stroke
Role:
Contributor
+ China Kadoorie Biobank Collaborative Group
Role:
Contributor
+ BioBank Japan Project Consortium
Role:
Contributor
+ ICAN Study Group
Role:
Contributor
+ CADISP Group
Role:
Contributor
Funding
Cancer Research UK
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 52
- Issue:
- 12
- Pages:
- 1303-1313
- Publication date:
- 2020-11-16
- Acceptance date:
- 2020-09-24
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Pmid:
-
33199917
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1146014
- Local pid:
- pubs:1146014
- Deposit date:
- 2021-01-19
Terms of use
- Copyright holder:
- Bakker, MK et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2020.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41588-020-00725-7
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