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Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Abstract:

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between rupture...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-020-00725-7

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Role:
Author
ORCID:
0000-0002-7887-9014
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Role:
Author
ORCID:
0000-0002-5860-1533
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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author

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Contributor
Role:
Contributor
Role:
Contributor
Publisher:
Springer Nature
Journal:
Nature Genetics More from this journal
Volume:
52
Issue:
12
Pages:
1303-1313
Publication date:
2020-11-16
Acceptance date:
2020-09-24
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
33199917
Language:
English
Keywords:
Pubs id:
1146014
Local pid:
pubs:1146014
Deposit date:
2021-01-19

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