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Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

Abstract:

Aims Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in their efficacy. This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response.

Methods and results A genome-wide study of the LDL-C and apolipoprotein B (ApoB) response to 40 mg simvastatin dail...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/eurheartj/ehs344

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Clinical Trial Service Unit
Role:
Author
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More from this funder
Funding agency for:
Hopewell, JC
Medical Research Council More from this funder
British Heart Foundation More from this funder
Roche Vitamins Ltd More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
European heart journal Journal website
Volume:
34
Issue:
13
Pages:
982-992
Publication date:
2013-04-05
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
URN:
uuid:b7d20a03-6de4-4c70-9176-2b36c9aa6f66
Source identifiers:
358301
Local pid:
pubs:358301

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