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Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

Abstract:

The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD are present in SARS-CoV-2 variants of concern that have emerged independently worldwide. For example, the B.1.1.7 lineage has a mutation (N501Y) in its Spike RBD that enhances binding to ACE2. There are also ACE2 alleles in humans with mutations in the RBD binding site. Here we perform a detailed affinity and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.70658

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Role:
Author
ORCID:
0000-0002-9263-6481
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Role:
Author
ORCID:
0000-0003-4233-5071
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Role:
Author
ORCID:
0000-0003-3386-4350
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Role:
Author
ORCID:
0000-0001-5847-5226
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Role:
Author
ORCID:
0000-0002-9014-5355
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Name:
Biotechnology and Biological Sciences Research Council
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
10
Article number:
e70658
Place of publication:
England
Publication date:
2021-08-26
Acceptance date:
2021-08-20
DOI:
EISSN:
2050-084X
Pmid:
34435953

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