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Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos).

Abstract:

Molecular markers provide a rapid and relatively inexpensive approach for assessing antimalarial drug susceptibility. We collected 884 Plasmodium falciparum-infected blood samples from 17 Lao provinces. Each sample was genotyped for 11 codons in the chloroquine resistance transporter (pfcrt), dihydrofolate reductase (pfdhfr), and dihydropteroate synthase (pfdhps) genes. The samples included 227 collected from patients recruited to clinical trials. The pfcrt K76T mutation was an excellent pred...

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Publication status:
Published

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Authors


Sudimack, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Tanomsing, N More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
77
Issue:
1
Pages:
36-43
Publication date:
2007-07-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:b7cf641d-40e5-4b97-9682-d2c3e455b5de
Source identifiers:
14648
Local pid:
pubs:14648

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