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Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease.

Abstract:

In confirmed late-onset (>65 years) Alzheimer's disease, we found a greater load, both of overall neuritic plaques and of cholinesterase-positive neuritic plaques, in the temporal cortex of carriers of the butyrylcholinesterase K variant (BCHE-K) aged <80 years than of all other patients. The differences were most striking in the case of cholinesterase-positive neuritic plaques. Among BCHE-K carriers, densities of such plaques were over six times higher in patients <80 years at death...

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Publication status:
Published

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Publisher copy:
10.1007/s004390000277

Authors


Lehmann, DJ More by this author
Litchfield, S More by this author
Journal:
Human genetics
Volume:
106
Issue:
4
Pages:
447-452
Publication date:
2000-04-05
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
URN:
uuid:b7ca9c75-4060-4908-913c-c0680310cead
Source identifiers:
195471
Local pid:
pubs:195471

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