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The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

Abstract:

OBJECTIVE: In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R(+/-)), at a whole-body level, increases resistance to inflammation and oxidative stress, but the underlying mechanisms are unclear. We hypothesized that by forming insulin-resistant heterodimers composed of one IGF-1Rαβ and one insulin receptor (IR), IRαβ complex in endothelial cells (ECs), IGF-1R reduces free IR, which reduces EC insulin sensitivity and generation of the antioxidant/anti-inflammatory signaling radical nitri...

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Publication status:
Published

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Publisher copy:
10.2337/db11-0197

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Journal:
Diabetes
Volume:
60
Issue:
8
Pages:
2169-2178
Publication date:
2011-08-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:b7ca7087-50cb-4609-851b-4247c2b32b85
Source identifiers:
155719
Local pid:
pubs:155719

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