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Integration of parallel opposing memories underlies memory extinction

Abstract:

Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of aversive memories in Drosophila requires specific dopaminergic neurons, which indicate that omission of punishment is remembered as a positive experience. Functional imaging reveal...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2018.08.021

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More from this funder
Funding agency for:
Waddell, S
Grant:
GAT3237
More from this funder
Funding agency for:
Waddell, S
Grant:
GAT3237
More from this funder
Funding agency for:
Waddell, S
Grant:
GAT3237
More from this funder
Funding agency for:
Felsenberg, J
Grant:
FE 1563/1-1
Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
175
Issue:
3
Pages:
709-722.e15
Publication date:
2018-09-20
Acceptance date:
2018-08-13
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
30245010
Language:
English
Keywords:
Pubs id:
pubs:922105
UUID:
uuid:b7b3ebe4-020f-4b19-841e-326f120f7802
Local pid:
pubs:922105
Deposit date:
2018-10-22

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