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Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria (CAN KNOW): an open-label randomized controlled trial

Abstract:

Plasmodium knowlesi is reported increasingly across Southeast Asia, and is the commonest cause of malaria in Malaysia. No randomized trials have assessed comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria.A randomized-controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria. Participants were included if >10kg, parasitemia <20,000/μL, and had a negative Pf-HR...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cid/cix779

Authors


More from this funder
Name:
Wellcome Trust
Grant:
Senior Fellow in Clinical Science (200909)
More from this funder
Name:
Malaysian Ministry of Health
Grant:
BP00500420
More from this funder
Name:
Australian National Health and Medical Research Council
Grant:
Programgrant#1037304,ProjectGrant #1045156
grant#1131932[theHOTNORTHinitiative
fellowshipstoNMA#1042072,TWY#605831,BEB#1088738,scholarshiptoMJG #1074795
Publisher:
Oxford University Press
Journal:
Clinical Infectious Diseases More from this journal
Volume:
66
Issue:
2
Pages:
229–236
Publication date:
2017-10-23
Acceptance date:
2017-08-29
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Language:
English
Keywords:
Pubs id:
pubs:737317
UUID:
uuid:b7b2c6bc-ce9d-43e6-9931-8b1fb107294a
Local pid:
pubs:737317
Source identifiers:
737317
Deposit date:
2017-10-20

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