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SYNTHESIS OF THE MANNOSIDASE INHIBITORS SWAINSONINE AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL AND OF THE RING CONTRACTED SWAINSONINES, (1S, 2R, 7R, 7AR)-1,2,7-TRIHYDROXYPYRROLIZIDINE AND (1S, 2R, 7S, 7AR)-1,2,7-TRIHYDROXYPYRROLIZIDINE

Abstract:
4,5-Anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol is a divergent intermediate for the efficient and practical syntheses of 1,4-dideoxy-1,4-imino-D-mannitol, swainsonine and of the ring contracted swainsonines, (1S, 2R, 7R, 7aR)-1,2,7-trihydroxypyrrolizidine and (1S, 2R, 7S, 7aR)-1,2,7-trihydroxypyrrolizidine. The effect on glycosidases of the ring contracted swainsonines is reported. © 1989.
Publication status:
Published

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Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
30
Issue:
51
Pages:
7261-7264
Publication date:
1989-01-01
DOI:
ISSN:
0040-4039
Language:
English
Pubs id:
pubs:43121
UUID:
uuid:b7b261db-88be-4274-a1a9-621067c31b8b
Local pid:
pubs:43121
Source identifiers:
43121
Deposit date:
2012-12-19

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