Journal article icon

Journal article

The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas.

Abstract:

The orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, are involved in gonadotroph differentiation, and SF-1 has been shown to activate the LH-beta and glycoprotein hormone alpha-subunit (alpha GSU) gene promoters. Pituitary adenomas from 34 patients [13 somatotroph tumors, 4 prolactinomas, and 17 clinically nonfunctioning pituitary adenomas (NFPAs)] were enzymatically dispersed and cultured in vitro for 48 h. Tissue culture medium was collected and assayed for LH, FSH, and al...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1210/jc.86.6.2476

Authors


Expand authors...
Journal:
Journal of clinical endocrinology and metabolism
Volume:
86
Issue:
6
Pages:
2476-2483
Publication date:
2001-06-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Source identifiers:
138415

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP