- Abstract:
-
The orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, are involved in gonadotroph differentiation, and SF-1 has been shown to activate the LH-beta and glycoprotein hormone alpha-subunit (alpha GSU) gene promoters. Pituitary adenomas from 34 patients [13 somatotroph tumors, 4 prolactinomas, and 17 clinically nonfunctioning pituitary adenomas (NFPAs)] were enzymatically dispersed and cultured in vitro for 48 h. Tissue culture medium was collected and assayed for LH, FSH, and al...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1210/jc.86.6.2476
-
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- Journal:
- The Journal of clinical endocrinology and metabolism
- Volume:
- 86
- Issue:
- 6
- Pages:
- 2476-2483
- Publication date:
- 2001-06-05
- DOI:
- EISSN:
-
1945-7197
- ISSN:
-
0021-972X
- URN:
-
uuid:b7afdc99-8cc4-4958-b356-53e0f9e34458
- Source identifiers:
-
138415
- Local pid:
- pubs:138415
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas.
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