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Journal article

The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas.

Abstract:

The orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, are involved in gonadotroph differentiation, and SF-1 has been shown to activate the LH-beta and glycoprotein hormone alpha-subunit (alpha GSU) gene promoters. Pituitary adenomas from 34 patients [13 somatotroph tumors, 4 prolactinomas, and 17 clinically nonfunctioning pituitary adenomas (NFPAs)] were enzymatically dispersed and cultured in vitro for 48 h. Tissue culture medium was collected and assayed for LH, FSH, and al...

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Publication status:
Published

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Publisher copy:
10.1210/jc.86.6.2476

Authors


Aylwin, SJ More by this author
Geddes, JF More by this author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
86
Issue:
6
Pages:
2476-2483
Publication date:
2001-06-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:b7afdc99-8cc4-4958-b356-53e0f9e34458
Source identifiers:
138415
Local pid:
pubs:138415

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