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Journal article

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults.

Abstract:

The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly subjects. Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE polymorphism on WM structure in healthy younger (aged 20-35 years) and older (aged 50-78 y...

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Publication status:
Published

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Publisher copy:
10.1038/mp.2010.90

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
Molecular psychiatry
Volume:
16
Issue:
9
Pages:
908-916
Publication date:
2011-09-01
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Source identifiers:
139248
Language:
English
Keywords:
Pubs id:
pubs:139248
UUID:
uuid:b7ad0f8e-7819-4d1d-9abb-17ae286191ef
Local pid:
pubs:139248
Deposit date:
2012-12-19

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