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The APOE ɛ4 allele modulates brain white matter integrity in healthy adults.

Abstract:

The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly subjects. Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE polymorphism on WM structure in healthy younger (aged 20-35 years) and older (aged 50-78 y...

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Publication status:
Published

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Publisher copy:
10.1038/mp.2010.90

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Filippini, N More by this author
Ebmeier, KP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Molecular psychiatry
Volume:
16
Issue:
9
Pages:
908-916
Publication date:
2011-09-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:b7ad0f8e-7819-4d1d-9abb-17ae286191ef
Source identifiers:
139248
Local pid:
pubs:139248

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