Journal article
High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase
- Abstract:
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Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishmania cyclins CYCA and CYC6. Here we describe the identification and synthesis of specific small molecule inhibitors of bacterially expressed Leishmania CRK3:CYC6 using ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Neglected Tropical Diseases Journal website
- Volume:
- 5
- Issue:
- 4
- Pages:
- e1033-e1033
- Publication date:
- 2011-04-05
- Acceptance date:
- 2011-03-10
- DOI:
- EISSN:
-
1935-2735
Item Description
- Keywords:
- Pubs id:
-
pubs:426563
- UUID:
-
uuid:b7ac0f17-98da-41fb-a2d5-8f53ae85b653
- Local pid:
- pubs:426563
- Source identifiers:
-
426563
- Deposit date:
- 2013-11-17
Terms of use
- Copyright holder:
- Walker et al
- Copyright date:
- 2011
- Notes:
- © 2011 Walker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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