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Journal article

The genetic and epigenetic basis of type 2 diabetes and obesity

Abstract:

Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health problems. The evidence for familial aggregation of both T2D and obesity is substantial. To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. However, the proportion of overall trait variance explained by these associated loci is modest (∼5-10% for T2D, ∼2% for body mass index (BMI)). Some of the familial aggregation ...

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Publisher copy:
10.1038/clpt.2012.149

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Journal:
Clinical Pharmacology and Therapeutics
Volume:
92
Issue:
6
Pages:
707-715
Publication date:
2012-12-05
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
URN:
uuid:b7a7b2c8-f9b9-4096-9902-9c07489b86a8
Source identifiers:
366726
Local pid:
pubs:366726
Language:
English

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