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Journal article

Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy.

Abstract:

Autosomal dominant optic atrophy (ADOA) is a slowly progressive optic neuropathy caused by mutations in the OPA1 gene. OPA1 is ubiquitously expressed and plays a key role in mitochondrial fusion. Heterozygous Opa1 mutant mice (B6; C3-Opa1(Q285STOP)), have previously been reported to develop visual defects and optic nerve changes. In this study, in vivo visual electrophysiological testing (ERGs and VEPs) was performed on 11-13 month old B6; C3-Opa1(Q285STOP) mice (n = 5) and age/sex matched wi...

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Publication status:
Published

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Publisher copy:
10.1016/j.exer.2011.07.004

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Charbel Issa, P More by this author
Perganta, G More by this author
Williams, PA More by this author
Davies, VJ More by this author
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Journal:
Experimental eye research
Volume:
93
Issue:
5
Pages:
771-777
Publication date:
2011-11-05
DOI:
EISSN:
1096-0007
ISSN:
0014-4835
URN:
uuid:b7a3c9df-ddeb-4af7-8095-89e6bb3e1ea8
Source identifiers:
167564
Local pid:
pubs:167564

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