- Abstract:
-
Age-related thymopoietic insufficiency has been proposed to be related to either defects in lymphohematopoietic progenitors or the thymic microenvironment. In this study, we examined whether keratinocyte growth factor (KGF), an epithelial cell-specific growth factor, could increase thymopoietic capacity in aged mice by restoration of the function of thymic epithelial cells (TECs). The thymic cellularity in KGF-treated aged mice increased about 4-fold compared to placebo-treated mice, resultin...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2006-08-043794
-
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- Journal:
- Blood
- Volume:
- 109
- Issue:
- 6
- Pages:
- 2529-2537
- Publication date:
- 2007-03-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:b7a0dd7f-9062-4a6e-97ef-5d89c70456ed
- Source identifiers:
-
309023
- Local pid:
- pubs:309023
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.
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