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Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.

Abstract:

Age-related thymopoietic insufficiency has been proposed to be related to either defects in lymphohematopoietic progenitors or the thymic microenvironment. In this study, we examined whether keratinocyte growth factor (KGF), an epithelial cell-specific growth factor, could increase thymopoietic capacity in aged mice by restoration of the function of thymic epithelial cells (TECs). The thymic cellularity in KGF-treated aged mice increased about 4-fold compared to placebo-treated mice, resultin...

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Publication status:
Published

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Journal:
Blood
Volume:
109
Issue:
6
Pages:
2529-2537
Publication date:
2007-03-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b7a0dd7f-9062-4a6e-97ef-5d89c70456ed
Source identifiers:
309023
Local pid:
pubs:309023

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