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Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis.

Abstract:

OBJECTIVE: We have previously identified a single-nucleotide polymorphism (SNP) haplotype involving the lymphotoxin alpha (LTA) and tumor necrosis factor (TNF) loci (termed haplotype LTA-TNF2) on chromosome 6 that shows differential association with rheumatoid arthritis (RA) on HLA-DRB1*0404 and *0401 haplotypes, suggesting the presence of additional non-HLA-DRB1 RA susceptibility genes on these haplotypes. To refine this association, we performed a case-control association study using both ...

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Publication status:
Published

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Publisher copy:
10.1002/art.20358

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Harney, SM More by this author
Rockett, K More by this author
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Journal:
Arthritis and rheumatism
Volume:
50
Issue:
7
Pages:
2122-2129
Publication date:
2004-07-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:b7a09edf-d999-499e-95c6-96e70bcbe8d9
Source identifiers:
108536
Local pid:
pubs:108536

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