Cancer drugs to treat birth defects.

Journal article

Identical mutations of the same genes can lead either to congenital malformations or to cancer, depending on their cellular and temporal context. The demonstration of activated RAS-ERK signaling in a mouse model of Apert syndrome suggests that drugs designed to inhibit this pathway in cancer may also delay the progression of several serious pediatric syndromes. ©2007 Nature Publishing Group.

Authors: Wilkie, A

• Publication status: Published
• Journal: Nature genetics
• Volume: 39
• Issue: 9
• Pages: 1057-1059
• Publication date: 2007-09-01
• DOI: 10.1038/ng0907-1057
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Disease Models, Animal; Antineoplastic Agents; Signal Transduction; ras Proteins; Models, Biological; Humans; Mice; Acrocephalosyndactylia; Congenital Abnormalities; Animals; Mitogen-Activated Protein Kinases