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Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection.

Abstract:

HIV-1 often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. We used single-genome amplification and sequencing of complete HIV genomes to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral set point at 1 year after the infection. We found that the rate of viral escape from CTL responses in a given patient decreases dramatically from acute infection to the viral set point. Using a novel...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00655-11

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Journal:
Journal of virology
Volume:
85
Issue:
20
Pages:
10518-10528
Publication date:
2011-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:b7907177-f7ad-4ae2-88d9-b75f5b1cf0af
Source identifiers:
170110
Local pid:
pubs:170110

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