- Abstract:
-
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/75165
-
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- Journal:
- Nature structural biology
- Volume:
- 7
- Issue:
- 5
- Pages:
- 389-393
- Publication date:
- 2000-05-05
- DOI:
- ISSN:
-
1072-8368
- URN:
-
uuid:b78e536b-8d6b-4cd4-915e-8eab40e3bedb
- Source identifiers:
-
23640
- Local pid:
- pubs:23640
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Structural basis of cell-cell adhesion by NCAM.
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