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Structural basis of cell-cell adhesion by NCAM.

Abstract:

The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the...

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Publication status:
Published

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Publisher copy:
10.1038/75165

Authors


Rasmussen, H More by this author
Kastrup, JS More by this author
Ikemizu, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
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Journal:
Nature structural biology
Volume:
7
Issue:
5
Pages:
389-393
Publication date:
2000-05-05
DOI:
ISSN:
1072-8368
URN:
uuid:b78e536b-8d6b-4cd4-915e-8eab40e3bedb
Source identifiers:
23640
Local pid:
pubs:23640

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