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Journal article

Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia.

Abstract:

BACKGROUND: Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia. METHODS AND RESULTS: We first screened sera from 52 idiopathic ataxia patients for binding of serum IgG antibodies to cerebellar neurons. One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then foun...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp-2011-301506

Authors


Becker, EB More by this author
Zuliani, L More by this author
Pettingill, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
83
Issue:
4
Pages:
437-440
Publication date:
2012-04-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:b77cf6b0-9f6a-4182-bdbd-5721be3396a8
Source identifiers:
321118
Local pid:
pubs:321118

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