- Abstract:
-
BACKGROUND: Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia. METHODS AND RESULTS: We first screened sera from 52 idiopathic ataxia patients for binding of serum IgG antibodies to cerebellar neurons. One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then foun...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1136/jnnp-2011-301506
-
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- Journal:
- Journal of neurology, neurosurgery, and psychiatry
- Volume:
- 83
- Issue:
- 4
- Pages:
- 437-440
- Publication date:
- 2012-04-05
- DOI:
- EISSN:
-
1468-330X
- ISSN:
-
0022-3050
- URN:
-
uuid:b77cf6b0-9f6a-4182-bdbd-5721be3396a8
- Source identifiers:
-
321118
- Local pid:
- pubs:321118
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia.
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