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Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection.

Abstract:

Human-virus-specific CD8+ T cells that are found during primary infection have been studied almost exclusively in the peripheral blood, and it is unclear whether these cells are regulated in the same way as those in secondary lymphoid tissue. We investigated, therefore, the control of apoptosis and telomere erosion of Epstein-Barr virus (EBV)-specific CD8+ T cells found in the blood and tonsils of the same patients during acute infectious mononucleosis (AIM). Although the clonal composition o...

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Publisher copy:
10.1182/blood-2003-06-1791

Authors


Soares, MV More by this author
Plunkett, FJ More by this author
Verbeke, CS More by this author
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Journal:
Blood
Volume:
103
Issue:
1
Pages:
162-167
Publication date:
2004-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b77bcf0b-4622-4b1f-8617-49ea48ebe054
Source identifiers:
32456
Local pid:
pubs:32456

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